Department of Physics Seminar Series: Michael Godsey
Monday, March 12, 2018 - 3:15pm

SB1 107, 1025 SW Mill Street
Free and open to the public
Light refreshments will be served


Michael Godsey
Department of Chemistry
Concordia University
"Using crystallography to probe the structures of life"


Diffraction of X-rays by crystals allows determination of the electronic structures that make up the molecules in the crystal lattice. X-ray Crystallography of biological molecules follows the same physical rules as small molecule crystallography, with some complications. Biological macromolecules are large, complex, and commonly display significant flexibility and solvent content. These factors make producing crystals difficult and their diffraction less than ideal. Nevertheless, crystallography is being used in the study of not only known proteins, but unknown and hypothetical proteins as well. The structure of one such hypothetical protein from B. cereus bears a resemblance to the structures of several ADP-ribosylating toxins, so we are using crystallography to probe its potential substrate binding and enzymatic function.


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