Department of Chemistry Seminar Series: Gaurav Sahay
Friday, April 12, 2019 - 3:15pm
Science Building 1, room 107, 1025 SW Mill Street
Free & open to the public

Oregon State University Assistant Professor of Pharmaceutical Science, Gaurav Sahay, will present at the Department of Chemistry's weekly seminar series

About Professor Sahay

Gaurav Sahay completed his postdoctoral research with Prof. Robert Langer and Prof. Daniel Anderson at Koch Institute for Integrative Cancer Research at MIT. He received his PhD from the Lab of Dr. Alexander Kabanov at the University Of Nebraska Medical Center (UNMC). He holds a Masters in Pharmacology from UNMC and Bachelors in Pharmacy from University of Pune.

Dr Sahay's work is on the interface of nanotechnology, cell biology and drug delivery. His lab is interested in unlocking the molecular mechanisms involved in the transport of nanoparticles to deliver small molecules, nucleic acids etc. inside cells. Most nanoparticles utilize intracellular trafficking to enter cells and even the most of efficacious amongst them remain trapped inside endosomes and the productive sites of escape remain elusive.

At MIT using a combination of high-throughput confocal imaging, small molecule library that impacts endocytosis, cell signaling and autophagy, Dr Sahay uncovered that exocytosis of lipid nanoparticles (LNPs) from the late endosomes was a major rate limiting step for siRNA delivery. His current interests lie in understanding nanoparticle mediated delivery of modified mRNA for protein production inside cells, with focus on therapeutic production of proteins in the treatment of lysosomal storage disorders. Sahay's long term goals are to gain mechanistic insights that provide a blueprint for development of new materials and targets for nanotechnology based therapies.

Dr Sahay has 21 publications in top tier journals including Nature Biotechnology, Nature Nanotechnology, PNAS, Advanced Materials, ACS Nano etc and has one of the most cited review article in the Journal of Controlled Release from his graduate school days with Prof. Kabanov. He is the winner of 2013 AAPS Postdoctoral Fellow Award and Nature’s Sci-Bx Innocentive challenge. 

About the Department of Chemistry

The Department of Chemistry maintains a teaching program of excellence at the undergraduate level and a graduate program emphasizing cutting-edge research in the chemistry of the environment, novel materials, and biological systems. The Department's curriculum, faculty, library, and facilities of the department are accredited by the American Chemical Society. | 503-725-8756